It should really also be noted that there are studies that have failed to help a central function for serotonin. In various studies, the metabolites five-HT and 5-HIAA in the cerebral spinal fluid of pathological gamblers had been unchanged (Roy et al., 1988, 1989 Bergh et al., 1997). Studies did obtain, on the other hand, proof of increased noradrenergic activity. The metabolite of noradrenaline, MHPG, was improved in pathological gamblers (Roy et al., 1988, 1989). Bergh et al. (1997) confirmed that locating and reported an raise in the concentration of noradrenaline. Other research that implicate serotonin have measured platelet monoamine oxidase (MAO) levels. Platelet MAO activity, a peripheral marker of 5-HT function, was located to be reduced in gamblers compared with nongamblers (Carrasco et al., 1994). In 1996, with a slightly larger sample (27 gamblers and 27 matched controls), Blanco and colleagues found evidence to support the Carrasco discovering (Blanco et al., 1996).

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